Allogeneic cell therapy bioprocess economics and optimization: downstream processing decisions
نویسندگان
چکیده
منابع مشابه
Allogeneic cell therapy bioprocess economics and optimization: downstream processing decisions.
AIM To develop a decisional tool to identify the most cost effective process flowsheets for allogeneic cell therapies across a range of production scales. MATERIALS & METHODS A bioprocess economics and optimization tool was built to assess competing cell expansion and downstream processing (DSP) technologies. RESULTS Tangential flow filtration was generally more cost-effective for the lower...
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For allogeneic cell therapies to reach their therapeutic potential, challenges related to achieving scalable and robust manufacturing processes will need to be addressed. A particular challenge is producing lot-sizes capable of meeting commercial demands of up to 10(9) cells/dose for large patient numbers due to the current limitations of expansion technologies. This article describes the appli...
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Background and Objective: In recent years, due to increasing number of patients with non-healing skin ulcers, skin substitutes have been used. Skin substitutes contain living cells causing faster and more effective wound healing. Therefore, research on the use of autologous and allogeneic cells such as fibroblasts in skin substitutes has attracted attentions. However, there are...
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BACKGROUND While advantages of biofuel have been widely reported, studies also highlight the challenges in large scale production of biofuel. Cost of ethanol and process energy use in cellulosic ethanol plants are dependent on technologies used for conversion of feedstock. Process modeling can aid in identifying techno-economic bottlenecks in a production process. A comprehensive techno-economi...
متن کاملOptimization of recombinant human erythropoietin therapy after allogeneic hematopoietic stem cell transplantation.
OBJECTIVE Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with prolonged anemia caused by defective erythropoietin (Epo) production. We enrolled 34 recipients of an allogeneic HSCT in three consecutive trials to determine the optimal utilization of recombinant human erythropoietin (rhEpo) therapy in this setting. MATERIALS AND METHODS In the first trial (n = 7), rhEpo ...
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ژورنال
عنوان ژورنال: Regenerative Medicine
سال: 2015
ISSN: 1746-0751,1746-076X
DOI: 10.2217/rme.15.29